Simvastatin induces apoptosis in human breast cancer cells in a NFκB-dependent manner and abolishes the anti-apoptotic signaling of TF/FVIIa and TF/FVIIa/FXa
M Åberg, M Wickström, A Siegbahn - Thrombosis research, 2008 - Elsevier
INTRODUCTION: Statins have benefits independent of the plasma cholesterol properties
among cancer patients and tissue factor (TF)/FVIIa induce PI3-kinase/AKT dependent anti-
apoptosis during serum starvation. We analyzed how simvastatin induces apoptosis in
human breast cancer cells and the influence of FVIIa and/or FXa on the proposed apoptosis.
MATERIALS AND METHODS: MDA-MB-231 cells were serum starved or treated with 5 μM
simvastatin and incubated with 10 and 100 nM FVIIa or 5/130 nM FVIIa/FX. RhoA was …
among cancer patients and tissue factor (TF)/FVIIa induce PI3-kinase/AKT dependent anti-
apoptosis during serum starvation. We analyzed how simvastatin induces apoptosis in
human breast cancer cells and the influence of FVIIa and/or FXa on the proposed apoptosis.
MATERIALS AND METHODS: MDA-MB-231 cells were serum starved or treated with 5 μM
simvastatin and incubated with 10 and 100 nM FVIIa or 5/130 nM FVIIa/FX. RhoA was …