HMG CoA reductase inhibitor suppresses the expression of tissue factor and plasminogen activator inhibitor-1 induced by angiotensin II in cultured rat aortic …
Y Kunieda, K Nakagawa, H Nishimura, H Kato… - Thrombosis research, 2003 - Elsevier
Background: It has been demonstrated that 3-hydroxy-3-methylglutaryl coenzyme A
reductase inhibitors (HRIs) reduce the incidence of acute cardiovascular events in patients
with hyperlipidemia. Recent reports have shown that the protective effects of these drugs
against cardiovascular events are also observed in patients without hyperlipidemia, but the
mechanism of this favorable effect still remains unclear. In this study, the effects of HRIs on
the endothelial regulation of thrombus formation were elucidated. Methods and results: The …
reductase inhibitors (HRIs) reduce the incidence of acute cardiovascular events in patients
with hyperlipidemia. Recent reports have shown that the protective effects of these drugs
against cardiovascular events are also observed in patients without hyperlipidemia, but the
mechanism of this favorable effect still remains unclear. In this study, the effects of HRIs on
the endothelial regulation of thrombus formation were elucidated. Methods and results: The …