The role of Langerhans cells in the sexual transmission of HIV
T Kawamura, SE Kurtz, A Blauvelt… - Journal of dermatological …, 2005 - Elsevier
Sexual transmission of HIV is the most common mode of infection in the global HIV
epidemic. In the absence of an effective vaccine, there is an urgent need for additional
strategies to prevent new HIV infections. An emerging body of evidence now indicates that
Langerhans cells (LC) are initial cellular targets in the sexual transmission of HIV, and CD4-
and CCR5-mediated infection of LC plays a crucial role in virus dissemination. However,
interactions between HIV and LC are complex. For example, it is evident that HIV can …
epidemic. In the absence of an effective vaccine, there is an urgent need for additional
strategies to prevent new HIV infections. An emerging body of evidence now indicates that
Langerhans cells (LC) are initial cellular targets in the sexual transmission of HIV, and CD4-
and CCR5-mediated infection of LC plays a crucial role in virus dissemination. However,
interactions between HIV and LC are complex. For example, it is evident that HIV can …