[HTML][HTML] Structural identification of a novel pro-inflammatory epoxyisoprostane phospholipid in mildly oxidized low density lipoprotein
AD Watson, G Subbanagounder, DS Welsbie… - Journal of Biological …, 1999 - ASBMB
One of the earliest steps in the development of the atherosclerotic lesion is the accumulation
of monocyte/macrophages within the vessel wall. Oxidized lipids present in minimally
modified-low density lipoproteins (MM-LDL) contribute to this process by activating
endothelial cells to express monocyte-specific adhesion molecules and chemoattractant
factors. A major focus of our group has been the isolation and characterization of the
biologically active oxidized lipids in MM-LDL. We have previously characterized three …
of monocyte/macrophages within the vessel wall. Oxidized lipids present in minimally
modified-low density lipoproteins (MM-LDL) contribute to this process by activating
endothelial cells to express monocyte-specific adhesion molecules and chemoattractant
factors. A major focus of our group has been the isolation and characterization of the
biologically active oxidized lipids in MM-LDL. We have previously characterized three …