Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial

SE Nissen, T Tsunoda, EM Tuzcu, P Schoenhagen… - Jama, 2003 - jamanetwork.com
Context Although low levels of high-density lipoprotein cholesterol (HDL-C) increase risk for
coronary disease, no data exist regarding potential benefits of administration of HDL-C or an
HDL mimetic. ApoA-I Milano is a variant of apolipoprotein AI identified in individuals in rural
Italy who exhibit very low levels of HDL. Infusion of recombinant ApoA-I Milano–
phospholipid complexes produces rapid regression of atherosclerosis in animal models.
Objective We assessed the effect of intravenous recombinant ApoA-I Milano/phospholipid …