For more than two decades, there has been continuing evidence of lipid oxidation playing a
central role in atherogenesis. The oxidation hypothesis of atherogenesis has evolved to
focus on specific proinflammatory oxidized phospholipids that result from the oxidation of
LDL phospholipids containing arachidonic acid and that are recognized by the innate
immune system in animals and humans. These oxidized phospholipids are largely
generated by potent oxidants produced by the lipoxygenase and myeloperoxidase …