Regulation of human T‐cell homing receptor expression in cutaneous bacterial infection
PA Sieling, A Legaspi, MT Ochoa, TH Rea… - …, 2007 - Wiley Online Library
We investigated the regulation of T‐cell homing receptors in infectious disease by
evaluating the cutaneous lymphocyte antigen (CLA) in human leprosy. We found that CLA‐
positive cells were enriched in the infectious lesions associated with restricting the growth of
the pathogen Mycobacterium leprae, as assessed by the clinical course of infection.
Moreover, CLA expression on T cells isolated from the peripheral blood of antigen‐
responsive tuberculoid leprosy patients increased in the presence of M. leprae (2ˇ 4‐fold …
evaluating the cutaneous lymphocyte antigen (CLA) in human leprosy. We found that CLA‐
positive cells were enriched in the infectious lesions associated with restricting the growth of
the pathogen Mycobacterium leprae, as assessed by the clinical course of infection.
Moreover, CLA expression on T cells isolated from the peripheral blood of antigen‐
responsive tuberculoid leprosy patients increased in the presence of M. leprae (2ˇ 4‐fold …
Summary
We investigated the regulation of T‐cell homing receptors in infectious disease by evaluating the cutaneous lymphocyte antigen (CLA) in human leprosy. We found that CLA‐positive cells were enriched in the infectious lesions associated with restricting the growth of the pathogen Mycobacterium leprae, as assessed by the clinical course of infection. Moreover, CLA expression on T cells isolated from the peripheral blood of antigen‐responsive tuberculoid leprosy patients increased in the presence of M. leprae (2ˇ4‐fold median increase; range 0ˇ8–6ˇ1, n = 17), but not in unresponsive lepromatous leprosy patients (1ˇ0‐fold median increase; range 0ˇ1–2ˇ2, n = 10; P < 0ˇ005). Mycobacterium leprae specifically up‐regulated the skin homing receptor, CLA, but not α4/β7, the intestinal homing receptor, which decreased on T cells of patients with tuberculoid leprosy after antigen stimulation (2ˇ2‐fold median decrease; range 1ˇ6–3ˇ4, n = 3). Our data indicate that CLA expression is regulated during the course of leprosy infection and suggest that T‐cell responsiveness to a microbial antigen directs antigen‐specific T cells to the site of infection.
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