Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses
SY Seong, P Matzinger - Nature Reviews Immunology, 2004 - nature.com
SY Seong, P Matzinger
Nature Reviews Immunology, 2004•nature.comIt is currently thought that immune responses are initiated by pathogen-associated molecular
patterns or by tissue-derived danger/alarm signals. Here, we propose that these two groups
of molecules might not be mutually exclusive. Many of them might be part of an
evolutionarily ancient alert system in which the hydrophobic portions of biological molecules
act, when exposed, as universal damage-associated molecular patterns to initiate repair,
remodelling and immunity.
patterns or by tissue-derived danger/alarm signals. Here, we propose that these two groups
of molecules might not be mutually exclusive. Many of them might be part of an
evolutionarily ancient alert system in which the hydrophobic portions of biological molecules
act, when exposed, as universal damage-associated molecular patterns to initiate repair,
remodelling and immunity.
Abstract
It is currently thought that immune responses are initiated by pathogen-associated molecular patterns or by tissue-derived danger/alarm signals. Here, we propose that these two groups of molecules might not be mutually exclusive. Many of them might be part of an evolutionarily ancient alert system in which the hydrophobic portions of biological molecules act, when exposed, as universal damage-associated molecular patterns to initiate repair, remodelling and immunity.
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