Tyrosine-phosphorylated and nonphosphorylated sodium channel β1 subunits are differentially localized in cardiac myocytes
JD Malhotra, V Thyagarajan, C Chen, LL Isom - Journal of Biological …, 2004 - jbc.org
Voltage-gated sodium channel α and β subunits expressed in mammalian heart are
differentially localized to t-tubules and intercalated disks. Sodium channel β subunits are
multifunctional molecules that participate in channel modulation and cell adhesion.
Reversible, receptor-mediated changes in β1 tyrosine phosphorylation modulate its ability to
recruit and associate with ankyrin. The purpose of the present study was to test our
hypothesis that tyrosine-phosphorylated β1 (pYβ1) and nonphosphorylated β1 subunits may …
differentially localized to t-tubules and intercalated disks. Sodium channel β subunits are
multifunctional molecules that participate in channel modulation and cell adhesion.
Reversible, receptor-mediated changes in β1 tyrosine phosphorylation modulate its ability to
recruit and associate with ankyrin. The purpose of the present study was to test our
hypothesis that tyrosine-phosphorylated β1 (pYβ1) and nonphosphorylated β1 subunits may …