Agonist-promoted ubiquitination of the G protein-coupled receptor CXCR4 mediates lysosomal sorting
A Marchese, JL Benovic - Journal of Biological Chemistry, 2001 - ASBMB
Ligand-induced trafficking plays an important role in the physiologic regulation of many G
protein-coupled receptors (GPCRs). Although numerous GPCRs are sorted to a degradative
pathway upon prolonged stimulation, the molecular events leading to degradation are
poorly understood. Here we report that the human immunodeficiency virus co-receptor
CXCR4 undergoes rapid agonist-promoted degradation by a process involving endocytosis
via clathrin-coated pits and subsequent sorting to lysosomes. Studies analyzing the sorting …
protein-coupled receptors (GPCRs). Although numerous GPCRs are sorted to a degradative
pathway upon prolonged stimulation, the molecular events leading to degradation are
poorly understood. Here we report that the human immunodeficiency virus co-receptor
CXCR4 undergoes rapid agonist-promoted degradation by a process involving endocytosis
via clathrin-coated pits and subsequent sorting to lysosomes. Studies analyzing the sorting …
