Improved assay for the quantification of 11-dehydrothromboxane B2 by gas chromatography—mass spectrometry
JD Morrow, TA Minton - Journal of Chromatography B: Biomedical Sciences …, 1993 - Elsevier
Endogenous thromboxane production is best assessed by the measurement of its excreted
metabolites, of which 11-dehydrothromboxane B 2 (11-dehydro-TxB 2) is most abundant.
Gas chromatographic—mass spectrometric assays have been developed for this compound
but suffer from the presence of co-eluting impurities which make the measurement of 11-
dehydro-TxB 2 difficult. Furthermore, these assays are often time-consuming. We now report
a modified assay for the measurement of this compound employing gas chromatography …
metabolites, of which 11-dehydrothromboxane B 2 (11-dehydro-TxB 2) is most abundant.
Gas chromatographic—mass spectrometric assays have been developed for this compound
but suffer from the presence of co-eluting impurities which make the measurement of 11-
dehydro-TxB 2 difficult. Furthermore, these assays are often time-consuming. We now report
a modified assay for the measurement of this compound employing gas chromatography …