Gastric epithelial cells liberate prostaglandin E 2 in response to cytokines as part of the
process of healing of gastric lesions. Treatment of the rat gastric epithelial cell line RGM1
with transforming growth factor-α and interleukin-1β leads to synergistic release of
arachidonate and production of prostaglandin E 2. Results with highly specific and potent
phospholipase A 2 inhibitors and with small interfering RNA show that cytosolic
phospholipase A 2-α and group IIA secreted phospholipase A 2 contribute to arachidonate …