Aspects of genetic susceptibility to human infectious diseases
AVS Hill - Annu. Rev. Genet., 2006 - annualreviews.org
Host genetic factors play a major role in determining differential susceptibility to major
infectious diseases of humans, such as malaria, HIV/AIDS, tuberculosis, and invasive
pneumococcal disease. Progress in identifying the relevant genetic loci has come from a
variety of approaches. Most convincing associations have been identified by case-control
studies assessing biologically plausible candidate genes. All six of the genes that have a
major effect on infectious disease susceptibility in humans have been identified in this way …
infectious diseases of humans, such as malaria, HIV/AIDS, tuberculosis, and invasive
pneumococcal disease. Progress in identifying the relevant genetic loci has come from a
variety of approaches. Most convincing associations have been identified by case-control
studies assessing biologically plausible candidate genes. All six of the genes that have a
major effect on infectious disease susceptibility in humans have been identified in this way …