In vivo veritas: the search for TB drug targets goes live
JD McKinney - Nature medicine, 2000 - nature.com
Nature medicine, 2000•nature.com
The termmicrobial persistence'describes a phenomenon whereby microorganisms which
are drug-susceptible when tested outside the body are nevertheless capable of surviving
within the body despite intensive therapy with the appropriate antimicrobial drug. In clinical
practice this phenomenon obviously has to do with the post-treatmentcarrier state'and with
post-treatment relapse. In short, it is this phenomenon which is responsible for our inability to
eradicate an infection from a person or a community by the use of drugs.—Walsh …
are drug-susceptible when tested outside the body are nevertheless capable of surviving
within the body despite intensive therapy with the appropriate antimicrobial drug. In clinical
practice this phenomenon obviously has to do with the post-treatmentcarrier state'and with
post-treatment relapse. In short, it is this phenomenon which is responsible for our inability to
eradicate an infection from a person or a community by the use of drugs.—Walsh …
Abstract
The termmicrobial persistence'describes a phenomenon whereby microorganisms which are drug-susceptible when tested outside the body are nevertheless capable of surviving within the body despite intensive therapy with the appropriate antimicrobial drug. In clinical practice this phenomenon obviously has to do with the post-treatmentcarrier state'and with post-treatment relapse. In short, it is this phenomenon which is responsible for our inability to eradicate an infection from a person or a community by the use of drugs.—Walsh McDermott, The Yale Journal of Biology and Medicine 30, 257 (1958).
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