In search of new cures for tuberculosis

M Protopopova, E Bogatcheva, B Nikonenko… - Medicinal …, 2007 - ingentaconnect.com
M Protopopova, E Bogatcheva, B Nikonenko, S Hundert, L Einck, CA Nacy
Medicinal Chemistry, 2007ingentaconnect.com
The last 10 years have seen resurgent industry activity in discovery and development of new
drugs for the treatment of tuberculosis (TB), a growing widespread and devastating (more
than 2 million deaths annually) bacterial infection that is of increasing concern in developing
and developed nations alike. This review describes drugs currently being evaluated in the
clinic for treatment of uncomplicated and drug resistant pulmonary TB, and updates the
literature on 5 new drugs that entered clinical trials in the last 4 years.
The last 10 years have seen resurgent industry activity in discovery and development of new drugs for the treatment of tuberculosis (TB), a growing widespread and devastating (more than 2 million deaths annually) bacterial infection that is of increasing concern in developing and developed nations alike. This review describes drugs currently being evaluated in the clinic for treatment of uncomplicated and drug resistant pulmonary TB, and updates the literature on 5 new drugs that entered clinical trials in the last 4 years.
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