Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients
NJ Deacon, A Tsykin, A Solomon, K Smith… - Science, 1995 - science.org
NJ Deacon, A Tsykin, A Solomon, K Smith, M Ludford-Menting, DJ Hooker, DA McPhee…
Science, 1995•science.orgA blood donor infected with human immunodeficiency virus-type 1 (HIV-1) and a cohort of
six blood or blood product recipients infected from this donor remain free of HIV-1-related
disease with stable and normal CD4 lymphocyte counts 10 to 14 years after infection. HIV-1
sequences from either virus isolates or patient peripheral blood mononuclear cells had
similar deletions in the nef gene and in the region of overlap of nef and the U3 region of the
long terminal repeat (LTR). Full-length sequencing of one isolate genome and amplification …
six blood or blood product recipients infected from this donor remain free of HIV-1-related
disease with stable and normal CD4 lymphocyte counts 10 to 14 years after infection. HIV-1
sequences from either virus isolates or patient peripheral blood mononuclear cells had
similar deletions in the nef gene and in the region of overlap of nef and the U3 region of the
long terminal repeat (LTR). Full-length sequencing of one isolate genome and amplification …
A blood donor infected with human immunodeficiency virus-type 1 (HIV-1) and a cohort of six blood or blood product recipients infected from this donor remain free of HIV-1-related disease with stable and normal CD4 lymphocyte counts 10 to 14 years after infection. HIV-1 sequences from either virus isolates or patient peripheral blood mononuclear cells had similar deletions in the nef gene and in the region of overlap of nef and the U3 region of the long terminal repeat (LTR). Full-length sequencing of one isolate genome and amplification of selected HIV-1 genome regions from other cohort members revealed no other abnormalities of obvious functional significance. These data show that survival after HIV infection can be determined by the HIV genome and support the importance of nef or the U3 region of the LTR in determining the pathogenicity of HIV-1.
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