Infection by human immunodeficiency virus—CD4 is not enough
JA Levy - New England Journal of Medicine, 1996 - Mass Medical Soc
JA Levy
New England Journal of Medicine, 1996•Mass Medical SocThe interaction between the human immunodeficiency virus (HIV) and its cellular target once
seemed fairly simple: the virus attached to the CD4 molecule on the cell surface, entered the
cell, and began its replicative cycle. 1 However, in the past few years, research has turned
up surprising evidence that the virus can bind to cells by means of receptors other than CD4.
These alternative receptors include galactosylceramide on brain and bowel cells and, when
the virus has formed a complex with antibody, Fc receptors. Binding through Fc receptors …
seemed fairly simple: the virus attached to the CD4 molecule on the cell surface, entered the
cell, and began its replicative cycle. 1 However, in the past few years, research has turned
up surprising evidence that the virus can bind to cells by means of receptors other than CD4.
These alternative receptors include galactosylceramide on brain and bowel cells and, when
the virus has formed a complex with antibody, Fc receptors. Binding through Fc receptors …
The interaction between the human immunodeficiency virus (HIV) and its cellular target once seemed fairly simple: the virus attached to the CD4 molecule on the cell surface, entered the cell, and began its replicative cycle.1 However, in the past few years, research has turned up surprising evidence that the virus can bind to cells by means of receptors other than CD4. These alternative receptors include galactosylceramide on brain and bowel cells and, when the virus has formed a complex with antibody, Fc receptors. Binding through Fc receptors can actually enhance viral infection.1
Recent studies of the early events in HIV . . .
The New England Journal Of Medicine