Short polybasic peptide sequences are potent inhibitors of PC5/6 and PC7: use of positional scanning-synthetic peptide combinatorial libraries as a tool for the …
M Fugere, J Appel, RA Houghten, I Lindberg… - Molecular …, 2007 - Elsevier
Positional scanning-synthetic peptide combinatorial libraries (PS-SPCLs) are powerful
molecular tools to identify enzyme substrate and potent inhibitory sequences and also to
provide crucial information about active site determinants. PS-SPCLs have been surveyed
for furin, proprotein convertase (PC) 2, PC1/3, and PACE4 and proven efficient to identify
potent peptidyl inhibitors in the low nanomolar range for furin and PC1/3. We report herein
the screenings of nonamidated and acetylated hexapeptide PS-SPCLs for PC5/6A and PC7 …
molecular tools to identify enzyme substrate and potent inhibitory sequences and also to
provide crucial information about active site determinants. PS-SPCLs have been surveyed
for furin, proprotein convertase (PC) 2, PC1/3, and PACE4 and proven efficient to identify
potent peptidyl inhibitors in the low nanomolar range for furin and PC1/3. We report herein
the screenings of nonamidated and acetylated hexapeptide PS-SPCLs for PC5/6A and PC7 …