Mifepristone: a novel estrogen-free daily contraceptive pill
DT Baird, A Brown, L Cheng, HOD Critchley, S Lin… - Steroids, 2003 - Elsevier
When the first synthetic progesterone antagonist (mifepristone) was synthesized over 20
years ago, it was clear that it had a potential as an antifertility agent. Research into the use of
antiprogestogens for contraception have concentrated on three general approaches:(1)
inhibition of ovulation,(2) inhibition of implantation and (3) disruption of implantation or
“menstrual induction”. The effect of mifepristone on the ovarian and endometrial cycle
depends on dose, timing and frequency of administration. Doses of 10mg per day or more …
years ago, it was clear that it had a potential as an antifertility agent. Research into the use of
antiprogestogens for contraception have concentrated on three general approaches:(1)
inhibition of ovulation,(2) inhibition of implantation and (3) disruption of implantation or
“menstrual induction”. The effect of mifepristone on the ovarian and endometrial cycle
depends on dose, timing and frequency of administration. Doses of 10mg per day or more …