Variable reduction in β-adrenergic sweat secretion in cystic fibrosis heterozygotes

K Sato, F Sato - The Journal of laboratory and clinical medicine, 1988 - translationalres.com
Because patients with cystic fibrosis (CF) consistently lack sweating response to
isoproterenol (ISO) in vivo and in vitro, we studied to what extent β-adrenergic defect is
expressed in CF heterozygotes. To improve the sensitivity and accuracy of determining the
sweating response to intradermal ISO (also containing theophylline and atropine), a water
vapor analyzer was used, and the peak sweat rates attained after intradermal injection in the
forearm of optimal concentrations of ISO and methacholine (MCH) were determined. The …