Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century
MR Capecchi - Nature reviews genetics, 2005 - nature.com
MR Capecchi
Nature reviews genetics, 2005•nature.comGene targeting in mouse embryonic stem cells has become the'gold standard'for
determining gene function in mammals. Since its inception, this technology has
revolutionized the study of mammalian biology and human medicine. Here I provide a
personal account of the work that led to the generation of gene targeting which now lies at
the centre of functional genomic analysis.
determining gene function in mammals. Since its inception, this technology has
revolutionized the study of mammalian biology and human medicine. Here I provide a
personal account of the work that led to the generation of gene targeting which now lies at
the centre of functional genomic analysis.
Abstract
Gene targeting in mouse embryonic stem cells has become the 'gold standard' for determining gene function in mammals. Since its inception, this technology has revolutionized the study of mammalian biology and human medicine. Here I provide a personal account of the work that led to the generation of gene targeting which now lies at the centre of functional genomic analysis.
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