[HTML][HTML] Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint
CL Rieder, H Maiato - Developmental cell, 2004 - cell.com
CL Rieder, H Maiato
Developmental cell, 2004•cell.comCells that cannot satisfy the spindle assembly checkpoint (SAC) are delayed in mitosis (D-
mitosis), a fact that has useful clinical ramifications. However, this delay is seldom
permanent, and in the presence of an active SAC most cells ultimately escape mitosis and
enter the next G1 as tetraploid cells. This review defines and discusses the various factors
that determine how long a cell remains in mitosis when it cannot satisfy the SAC and also
discusses the cell's subsequent fate.
mitosis), a fact that has useful clinical ramifications. However, this delay is seldom
permanent, and in the presence of an active SAC most cells ultimately escape mitosis and
enter the next G1 as tetraploid cells. This review defines and discusses the various factors
that determine how long a cell remains in mitosis when it cannot satisfy the SAC and also
discusses the cell's subsequent fate.
Abstract
Cells that cannot satisfy the spindle assembly checkpoint (SAC) are delayed in mitosis (D-mitosis), a fact that has useful clinical ramifications. However, this delay is seldom permanent, and in the presence of an active SAC most cells ultimately escape mitosis and enter the next G1 as tetraploid cells. This review defines and discusses the various factors that determine how long a cell remains in mitosis when it cannot satisfy the SAC and also discusses the cell's subsequent fate.
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