A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa

EL Berson, B Rosner, MA Sandberg… - Archives of …, 1993 - jamanetwork.com
• Objective.—To determine whether supplements of vitamin A or vitamin E alone or in
combination affect the course of retinitis pigmentosa. Design.—Randomized, controlled,
double-masked trial with 2× 2 factorial design and duration of 4 to 6 years.
Electroretinograms, visual field area, and visual acuity were measured annually. Setting.—
Clinical research facility. Patients.—601 patients aged 18 through 49 years with retinitis
pigmentosa meeting preset eligibility criteria. Ninety-five percent of the patients completed …