Effect of several growth factors on canine flexor tendon fibroblast proliferation and collagen synthesis in vitro
S Thomopoulos, FL Harwood, MJ Silva, D Amiel… - The Journal of hand …, 2005 - Elsevier
PURPOSE: Growth factor delivery may be useful to accelerate the rate of tendon healing.
Before in vivo use, however, the effects of growth factors on tendon cells need to be well
characterized. The purpose of this study was to evaluate the effects of 4 growth factors on
intrasynovial tendon fibroblast proliferation and collagen production in vitro. Our first
hypothesis was that platelet-derived growth factor BB (PDGF-BB) and basic fibroblast growth
factor (bFGF) would promote cell proliferation and collagen production. Our second …
Before in vivo use, however, the effects of growth factors on tendon cells need to be well
characterized. The purpose of this study was to evaluate the effects of 4 growth factors on
intrasynovial tendon fibroblast proliferation and collagen production in vitro. Our first
hypothesis was that platelet-derived growth factor BB (PDGF-BB) and basic fibroblast growth
factor (bFGF) would promote cell proliferation and collagen production. Our second …