[HTML][HTML] Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation
L Rössig, C Badorff, Y Holzmann, AM Zeiher… - Journal of Biological …, 2002 - ASBMB
Signaling via the phosphoinositide 3-kinase (PI3K)/AKT pathway is crucial for the regulation
of endothelial cell (EC) proliferation and survival, which involves the AKT-dependent
phosphorylation of the DNA repair protein p21 Cip1 at Thr-145. Because p21 Cip1 is a short-
lived protein with a high proteasomal degradation rate, we investigated the regulation of p21
Cip1 protein levels by PI3K/AKT-dependent signaling. The PI3K inhibitors Ly294002 and
wortmannin reduced p21 Cip1 protein abundance in human umbilical vein EC. However …
of endothelial cell (EC) proliferation and survival, which involves the AKT-dependent
phosphorylation of the DNA repair protein p21 Cip1 at Thr-145. Because p21 Cip1 is a short-
lived protein with a high proteasomal degradation rate, we investigated the regulation of p21
Cip1 protein levels by PI3K/AKT-dependent signaling. The PI3K inhibitors Ly294002 and
wortmannin reduced p21 Cip1 protein abundance in human umbilical vein EC. However …