[HTML][HTML] Stress pathways and heart failure

KR Chien - Cell, 1999 - cell.com
Cell, 1999cell.com
The study of complex heart diseases has always been a vexing task, akin to solving a 1000-
part jigsaw puzzle with few obvious connecting pieces. Acquired cardiovascular diseases,
such as atherogenesis and heart failure, arise via the interaction of environmental factors
and genetic susceptibility to produce complicated lesions that cannot be explained by a
single gene or pathway. Distinguishing primary from secondary events, proving causality,
and finding the intersecting pieces has proven a significant challenge. Nevertheless, as …
The study of complex heart diseases has always been a vexing task, akin to solving a 1000-part jigsaw puzzle with few obvious connecting pieces. Acquired cardiovascular diseases, such as atherogenesis and heart failure, arise via the interaction of environmental factors and genetic susceptibility to produce complicated lesions that cannot be explained by a single gene or pathway. Distinguishing primary from secondary events, proving causality, and finding the intersecting pieces has proven a significant challenge. Nevertheless, as evidenced by the pioneering work on the LDL receptor pathway in atherogenesis, genetic-based analysis of relatively rare diseases that exhibit the clinical cardiovascular phenotype of interest can yield mechanistic insight into complex heart diseases (
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