[HTML][HTML] Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression
K Balasubramanyam, M Altaf, RA Varier… - Journal of Biological …, 2004 - ASBMB
Histone acetylation is a diagnostic feature of transcriptionally active genes. The proper
recruitment and function of histone acetyltransferases (HATs) and deacetylases (HDACs)
are key regulatory steps for gene expression and cell cycle. Functional defects of either of
these enzymes may lead to several diseases, including cancer. HATs and HDACs thus are
potential therapeutic targets. Here we report that garcinol, a polyisoprenylated
benzophenone derivative from Garcinia indica fruit rind, is a potent inhibitor of histone …
recruitment and function of histone acetyltransferases (HATs) and deacetylases (HDACs)
are key regulatory steps for gene expression and cell cycle. Functional defects of either of
these enzymes may lead to several diseases, including cancer. HATs and HDACs thus are
potential therapeutic targets. Here we report that garcinol, a polyisoprenylated
benzophenone derivative from Garcinia indica fruit rind, is a potent inhibitor of histone …