[HTML][HTML] Alterations of protein expression in macrophages in response to Candida albicans infection

YK Shin, KY Kim, YK Paik - Molecules and cells, 2005 - Elsevier
Although macrophages are an important first line of cellular defense, they are unable to
effectively kill phagocytosed C. albicans. To determine the physiological basis of this
inability, we investigated the alterations of macrophage proteins caused by C. albicans
infection. Since the formation of C. albicans hyphae caused cell death, proteins were
prepared 3 h after infection and examined by two-dimensional gel electrophoresis (2-DE).
The most prominent changes were in glycolytic enzymes, which could have caused energy …