Under starvation conditions, the majority of intracellular degradation occurs at the lysosome
or vacuole by the autophagy pathway. The cytoplasmic substrates destined for degradation
are packaged inside unique double-membrane transport vesicles called autophagosomes
and are targeted to the lysosome/vacuole for subsequent breakdown and recycling. Genetic
analyses of yeast autophagy mutants, apg and aut, have begun to identify the molecular
machinery as well as indicate a substantial overlap with the biosynthetic cytoplasm to …