Identification of proteoglycans as the APRIL-specific binding partners
K Ingold, A Zumsteg, A Tardivel, B Huard… - Journal of Experimental …, 2005 - rupress.org
K Ingold, A Zumsteg, A Tardivel, B Huard, QG Steiner, TG Cachero, F Qiang, L Gorelik…
Journal of Experimental Medicine, 2005•rupress.orgRESULTS The mature NH2-terminal sequence of APRIL is required for binding to the APRIL-
specific binding partner We have previously shown that APRIL displayed significant binding
to various cell lines that did not express the two known APRIL receptors, TACI and BCMA.
Consistent with the absence of BCMA and TACI, these cells did not interact with BAFF,
suggesting the existence of an additional, widely distributed receptor for APRIL with little or
no affin-
specific binding partner We have previously shown that APRIL displayed significant binding
to various cell lines that did not express the two known APRIL receptors, TACI and BCMA.
Consistent with the absence of BCMA and TACI, these cells did not interact with BAFF,
suggesting the existence of an additional, widely distributed receptor for APRIL with little or
no affin-
RESULTS The mature NH2-terminal sequence of APRIL is required for binding to the APRIL-specific binding partner
We have previously shown that APRIL displayed significant binding to various cell lines that did not express the two known APRIL receptors, TACI and BCMA. Consistent with the absence of BCMA and TACI, these cells did not interact with BAFF, suggesting the existence of an additional, widely distributed receptor for APRIL with little or no affin-
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