Transforming growth factor-β-related proteins: an ancestral and widespread superfamily of cytokines in metazoans
A Herpin, C Lelong, P Favrel - Developmental & Comparative Immunology, 2004 - Elsevier
Members of the transforming growth factor β (TGF-β) superfamily of cell signalling
polypeptides have attracted much attention because of their ability, from nematodes to
mammals, to control cellular functions that in turn, regulate embryo development and tissue
homeostasis. On the basis of structure similarities, the TGF-β members (ligands, receptors
and Smads) are subdivided into TGF-β sensu stricto, bone morphogenetic proteins (BMP)
and activins. Although BMP is the best characterized pathway in metazoans, recent findings …
polypeptides have attracted much attention because of their ability, from nematodes to
mammals, to control cellular functions that in turn, regulate embryo development and tissue
homeostasis. On the basis of structure similarities, the TGF-β members (ligands, receptors
and Smads) are subdivided into TGF-β sensu stricto, bone morphogenetic proteins (BMP)
and activins. Although BMP is the best characterized pathway in metazoans, recent findings …