Stearoyl-CoA desaturase deficiency, hypercholesterolemia, cholestasis, and diabetes
AD Attie, MT Flowers, JB Flowers, AK Groen… - Nutrition …, 2007 - academic.oup.com
Nutrition reviews, 2007•academic.oup.com
Previous studies showed that mice deficient in Scd1 had a reduced level of liver triglyceride
and an improvement in insulin sensitivity. We studied Scd1--/-mice on a very low-fat, high-
carbohydrate lipogenic diet. The animals were almost entirely devoid of high-density
lipoprotein (HDL). Nonetheless, they were hypercholesterolemic and had cholestasis. These
changes were reversible with oil containing both mono-and polyunsaturated fat, but not
entirely reversible with just triolein, suggesting that Scd1 deficiency increased the …
and an improvement in insulin sensitivity. We studied Scd1--/-mice on a very low-fat, high-
carbohydrate lipogenic diet. The animals were almost entirely devoid of high-density
lipoprotein (HDL). Nonetheless, they were hypercholesterolemic and had cholestasis. These
changes were reversible with oil containing both mono-and polyunsaturated fat, but not
entirely reversible with just triolein, suggesting that Scd1 deficiency increased the …
Abstract
Previous studies showed that mice deficient in Scd1 had a reduced level of liver triglyceride and an improvement in insulin sensitivity. We studied Scd1--/-mice on a very low-fat, high-carbohydrate lipogenic diet. The animals were almost entirely devoid of high-density lipoprotein (HDL). Nonetheless, they were hypercholesterolemic and had cholestasis. These changes were reversible with oil containing both mono- and polyunsaturated fat, but not entirely reversible with just triolein, suggesting that Scd1 deficiency increased the requirement for polyunsaturated fat. We also found that the Scd1--/- mice on a normal chow diet had dramatically improved insulin sensitivity. However, leptinob/ob Scd1--/-mice had worse diabetes than leptinob/ob Scd1wt/wtmice.
Oxford University Press