TAZ interacts with TTF-1 and regulates expression of surfactant protein-C
KS Park, JA Whitsett, T Di Palma, JH Hong… - Journal of Biological …, 2004 - jbc.org
Thyroid transcription factor-1 (TTF-1/Nkx-2.1) is required for formation of the lung and
differentiation of peripheral respiratory epithelial cells. TTF-1 activates transcription of target
genes, including the surfactant proteins critical for lung function. A recently identified protein
TAZ (transcriptional co-activator with PDZ-binding motif) contains a WW domain and a
COOH-terminal PDZ-binding motif that are proposed to mediate its interactions with various
transcriptional proteins. To determine the role of TAZ in the regulation of gene expression in …
differentiation of peripheral respiratory epithelial cells. TTF-1 activates transcription of target
genes, including the surfactant proteins critical for lung function. A recently identified protein
TAZ (transcriptional co-activator with PDZ-binding motif) contains a WW domain and a
COOH-terminal PDZ-binding motif that are proposed to mediate its interactions with various
transcriptional proteins. To determine the role of TAZ in the regulation of gene expression in …