DARPP-32: an integrator of neurotransmission
P Svenningsson, A Nishi, G Fisone… - Annu. Rev …, 2004 - annualreviews.org
Dopamine-and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), was identified
initially as a major target for dopamine and protein kinase A (PKA) in striatum. However,
recent advances now indicate that regulation of the state of DARPP-32 phosphorylation
provides a mechanism for integrating information arriving at dopaminoceptive neurons, in
multiple brain regions, via a variety of neurotransmitters, neuromodulators, neuropeptides,
and steroid hormones. Activation of PKA or PKG stimulates DARPP-32 phosphorylation at …
initially as a major target for dopamine and protein kinase A (PKA) in striatum. However,
recent advances now indicate that regulation of the state of DARPP-32 phosphorylation
provides a mechanism for integrating information arriving at dopaminoceptive neurons, in
multiple brain regions, via a variety of neurotransmitters, neuromodulators, neuropeptides,
and steroid hormones. Activation of PKA or PKG stimulates DARPP-32 phosphorylation at …
