Little is currently known about the role of γδ^{+ +} T cells in disease pathogenesis. We have demonstrated elevated levels of γδ⁺ T cells in the peripheral blood and cerebrospinal fluid of patients with Wilson's disease compared with other neurological diseases. The percentage of of γδ⁺ T cells was between 20% and 50% in all patient groups: of γδ⁺ T cells in blood correlated with copper concentrations. The antigen reactivity of γδ^{+ +} T cells and how the antigens relate to the of γδ⁺ T cells found in WD remains unknown. It remains unclear whether there is a direct reason for the elevated of γδ⁺ T cells population found in WD. Immunohistochemistry of frozen autopsy material from brain and liver of WD patients could allow exact localization of γδ⁺ T cells and heat shock proteins in future studies.