The progress in understanding the mechanisms of T cell activation, inactivation and
modulation has been translated into different immunotherapeutic strategies aiming at
treating multiple sclerosis (MS). Key attack points for selective immunointervention in MS
include modulation of antigen recognition, costimulation blockade, induction of regulatory
cells, deviation to non-pathogenic or protective responses, neutralization of proinflammatory
cytokines and administration of anti-inflammatory cytokines. In addition, several attempts …