Cryptococcus neoformans: intracellular or extracellular?

SM Levitz - TRENDS in Microbiology, 2001 - cell.com
TRENDS in Microbiology, 2001cell.com
presented compelling in vitro and in vivo evidence that the encapsulated fungus
Cryptococcus neoformans is a facultative intracellular parasite of macrophages.
Experimental support for this concept dates back nearly 30 years, when it was demonstrated
that C. neoformans can not only survive in human macrophages in vitro, but also can
actually grow better inside certain macrophage populations than in tissue-culture medium
presented compelling in vitro and in vivo evidence that the encapsulated fungus Cryptococcus neoformans is a facultative intracellular parasite of macrophages. Experimental support for this concept dates back nearly 30 years, when it was demonstrated that C. neoformans can not only survive in human macrophages in vitro, but also can actually grow better inside certain macrophage populations than in tissue-culture medium
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