[HTML][HTML] The mmaA2 gene of Mycobacterium tuberculosis encodes the distal cyclopropane synthase of the α-mycolic acid
MS Glickman - Journal of Biological Chemistry, 2003 - ASBMB
Infection with Mycobacterium tuberculosis (Mtb) remains a severe global health problem that
has prompted an aggressive search for new antibiotic targets and vaccine strategies for this
persistent pathogen. Recently, a wide variety of genetic determinants of Mtb pathogenicity
have been identified, including several genes involved in the biogenesis of the complex Mtb
cell envelope. Among these are the mycolic acid cyclopropane synthases, a family of
proteins that modify the major cell envelope lipids of Mtb with a diversity of cyclopropane …
has prompted an aggressive search for new antibiotic targets and vaccine strategies for this
persistent pathogen. Recently, a wide variety of genetic determinants of Mtb pathogenicity
have been identified, including several genes involved in the biogenesis of the complex Mtb
cell envelope. Among these are the mycolic acid cyclopropane synthases, a family of
proteins that modify the major cell envelope lipids of Mtb with a diversity of cyclopropane …