[HTML][HTML] MMAS-1, the branch point between cis-and trans-cyclopropane-containing oxygenated mycolates in Mycobacterium tuberculosis
Y Yuan, DC Crane, JM Musser, S Sreevatsan… - Journal of Biological …, 1997 - ASBMB
The proportion of mycolic acid containing trans-substituents at the proximal position of the
meromycolate chain is an important determinant of fluidity of the mycobacterial cell wall and
is directly related to the sensitivity of mycobacterial species to hydrophobic antibiotics.
MMAS-1, an enzyme encoded in the gene cluster responsible for the biosynthesis of
methoxymycolates, was overexpressed in Mycobacterium tuberculosis and shown to result
in the overproduction of trans-cyclopropane and trans-olefin-containing oxygenated mycolic …
meromycolate chain is an important determinant of fluidity of the mycobacterial cell wall and
is directly related to the sensitivity of mycobacterial species to hydrophobic antibiotics.
MMAS-1, an enzyme encoded in the gene cluster responsible for the biosynthesis of
methoxymycolates, was overexpressed in Mycobacterium tuberculosis and shown to result
in the overproduction of trans-cyclopropane and trans-olefin-containing oxygenated mycolic …