Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid

DR Senger, SJ Galli, AM Dvorak, CA Perruzzi… - Science, 1983 - science.org
DR Senger, SJ Galli, AM Dvorak, CA Perruzzi, VS Harvey, HF Dvorak
Science, 1983science.org
Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly
increases microvascular permeability. Similar activity is also secreted by these tumor cells
and a variety of other tumor cell lines in vitro. The permeability-increasing activity purified
from either the culture medium or ascites fluid of one tumor, the guinea pig line 10
hepatocarcinoma, is a 34,000-to 42,000-dalton protein distinct from other known
permeability factors.
Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability. Similar activity is also secreted by these tumor cells and a variety of other tumor cell lines in vitro. The permeability-increasing activity purified from either the culture medium or ascites fluid of one tumor, the guinea pig line 10 hepatocarcinoma, is a 34,000- to 42,000-dalton protein distinct from other known permeability factors.
AAAS