Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: potential mechanism for sensitization to liver damage
M Guebre-Xabier, SQ Yang, HZ Lin, R Schwenk… - Hepatology, 2000 - journals.lww.com
Although obesity-related fatty livers are vulnerable to damage from endotoxin, the
mechanisms involved remain obscure. The purpose of this study was to determine if
immunologic priming might be involved by determining if fatty livers resemble normal livers
that have been sensitized to endotoxin damage by Propionibacterium acnes infection. The
latter induces interleukin (IL)-12 and-18, causing a selective reduction of CD4+ NK T cells,
diminished IL-4 production, deficient production of T-helper type 2 (Th-2) cytokines (eg, IL …
mechanisms involved remain obscure. The purpose of this study was to determine if
immunologic priming might be involved by determining if fatty livers resemble normal livers
that have been sensitized to endotoxin damage by Propionibacterium acnes infection. The
latter induces interleukin (IL)-12 and-18, causing a selective reduction of CD4+ NK T cells,
diminished IL-4 production, deficient production of T-helper type 2 (Th-2) cytokines (eg, IL …