[HTML][HTML] The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307

V Aguirre, T Uchida, L Yenush, R Davis… - Journal of Biological …, 2000 - ASBMB
Tumor necrosis factor α (TNFα) inhibits insulin action, in part, through serine
phosphorylation of IRS proteins; however, the phosphorylation sites that mediate the
inhibition are unknown. TNFα promotes multipotential signal transduction cascades,
including the activation of the Jun NH 2-terminal kinase (JNK). Endogenous JNK associates
with IRS-1 in Chinese hamster ovary cells. Anisomycin, a strong activator of JNK in these
cells, stimulates the activity of JNK bound to IRS-1 and inhibits the insulin-stimulated …