Compartmentalization of cyclic AMP-dependent protein kinase (PKA) is achieved through
association with A-kinase anchoring proteins (AKAPs). AKAPs are a group of structurally
diverse proteins with the common function of binding to the regulatory subunit of PKA and
confining the holoenzyme to discrete locations within the cell. This mode of regulation
ensures that PKA is exposed to isolated cAMP gradients, which allows for efficient catalytic
activation and accurate substrate selection. Several AKAPs coordinate multiple members of …