The role of overexpression and gene amplification of cyclin D1 in intrahepatic cholangiocarcinoma
K Sugimachi, S Aishima, K Taguchi, S Tanaka… - Journal of …, 2001 - Elsevier
Background/Aims: Intrahepatic cholangiocarcinoma (ICC) is a primary liver malignant tumor
with an extremely poor prognosis, but less attention has been directed to factors related to
molecular carcinogenesis, including cell cycle proteins. We examined the expression and
gene amplification of cyclin D1, the cell cycle regulating protein. Our objective was to
evaluate correlations with clinicopathological factors in ICC. Methods: Cyclin D1
overexpression and cellular proliferative activity (Ki-67 labeling index) were investigated …
with an extremely poor prognosis, but less attention has been directed to factors related to
molecular carcinogenesis, including cell cycle proteins. We examined the expression and
gene amplification of cyclin D1, the cell cycle regulating protein. Our objective was to
evaluate correlations with clinicopathological factors in ICC. Methods: Cyclin D1
overexpression and cellular proliferative activity (Ki-67 labeling index) were investigated …