Neuraminidase Expressed by Streptococcus pneumoniae Desialylates the Lipopolysaccharide of Neisseria meningitidis and Haemophilus influenzae: a Paradigm …
EA Shakhnovich, SJ King, JN Weiser - Infection and immunity, 2002 - Am Soc Microbiol
EA Shakhnovich, SJ King, JN Weiser
Infection and immunity, 2002•Am Soc MicrobiolABSTRACT Both Neisseria meningitidis and Haemophilus influenzae are capable of
mimicking host structures by decorating their lipopolysaccharides with sialic acid. We show
that a neuraminidase expressed by Streptococcus pneumoniae (NanA) is able to desialylate
the cell surfaces of both these species, which reside in and possibly compete for the same
host niche.
mimicking host structures by decorating their lipopolysaccharides with sialic acid. We show
that a neuraminidase expressed by Streptococcus pneumoniae (NanA) is able to desialylate
the cell surfaces of both these species, which reside in and possibly compete for the same
host niche.
Abstract
Both Neisseria meningitidis and Haemophilus influenzae are capable of mimicking host structures by decorating their lipopolysaccharides with sialic acid. We show that a neuraminidase expressed by Streptococcus pneumoniae (NanA) is able to desialylate the cell surfaces of both these species, which reside in and possibly compete for the same host niche.
American Society for Microbiology