Influenza virus neuraminidase: structure, antibodies, and inhibitors
PM Colman - Protein Science, 1994 - Wiley Online Library
Protein Science, 1994•Wiley Online Library
The determination of the 3‐dimensional structure of the influenza virus neuraminidase in
1983 has served as a platform for understanding interactions between antibodies and
protein antigens, for investigating antigenic variation in influenza viruses, and for devising
new inhibitors of the enzyme. That work is reviewed here, together with more recent
developments that have resulted in one of the inhibitors entering clinical trials as an anti‐
influenza virus drug.
1983 has served as a platform for understanding interactions between antibodies and
protein antigens, for investigating antigenic variation in influenza viruses, and for devising
new inhibitors of the enzyme. That work is reviewed here, together with more recent
developments that have resulted in one of the inhibitors entering clinical trials as an anti‐
influenza virus drug.
Abstract
The determination of the 3‐dimensional structure of the influenza virus neuraminidase in 1983 has served as a platform for understanding interactions between antibodies and protein antigens, for investigating antigenic variation in influenza viruses, and for devising new inhibitors of the enzyme. That work is reviewed here, together with more recent developments that have resulted in one of the inhibitors entering clinical trials as an anti‐influenza virus drug.
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