[HTML][HTML] Synthetic soluble analogs of galactosylceramide (GalCer) bind to the V3 domain of HIV-1 gp120 and inhibit HIV-1-induced fusion and entry
Galactosylceramide (GalCer) is an alternative receptor allowing human immunodeficiency
virus (HIV)-1 entry into CD4-negative cells of neural and colonic origin. Several lines of
evidence suggest that this glycosphingolipid recognizes the V3 region of HIV-1 surface
envelope glycoprotein gp120. Since the V3 loop plays a key role in the fusion process
driven by HIV-1, we decided to synthesize soluble analogs of GalCer with the aim to develop
a new class of anti-HIV-1 agents that could neutralize HIV-1 infection through masking of the …
virus (HIV)-1 entry into CD4-negative cells of neural and colonic origin. Several lines of
evidence suggest that this glycosphingolipid recognizes the V3 region of HIV-1 surface
envelope glycoprotein gp120. Since the V3 loop plays a key role in the fusion process
driven by HIV-1, we decided to synthesize soluble analogs of GalCer with the aim to develop
a new class of anti-HIV-1 agents that could neutralize HIV-1 infection through masking of the …