[HTML][HTML] The evolutionary history of the CCR5-Δ32 HIV-resistance mutation
AP Galvani, J Novembre - Microbes and Infection, 2005 - Elsevier
The CCR5 chemokine receptor is exploited by HIV-1 to gain entry into CD4+ T cells. A
deletion mutation (Δ32) confers resistance against HIV by obliterating the expression of the
receptor on the cell surface. Intriguingly, this allele is young in evolutionary time, yet it has
reached relatively high frequencies in Europe. These properties indicate that the mutation
has been under intense positive selection. HIV-1 has not exerted selection for long enough
on the human population to drive the CCR5-Δ32 allele to current frequencies, fueling debate …
deletion mutation (Δ32) confers resistance against HIV by obliterating the expression of the
receptor on the cell surface. Intriguingly, this allele is young in evolutionary time, yet it has
reached relatively high frequencies in Europe. These properties indicate that the mutation
has been under intense positive selection. HIV-1 has not exerted selection for long enough
on the human population to drive the CCR5-Δ32 allele to current frequencies, fueling debate …