Cleavage, aggregation and toxicity of the expanded androgen receptor in spinal and bulbar muscular atrophy
DE Merry, Y Kobayashi, CK Bailey… - Human Molecular …, 1998 - academic.oup.com
DE Merry, Y Kobayashi, CK Bailey, AA Taye, KH Fischbeck
Human Molecular Genetics, 1998•academic.oup.comSpinal and bulbar muscular atrophy (SBMA) is a neurodegenerative disease caused by the
expansion of a polyglutamine repeat within the androgen receptor (AR). We have studied
the mutant AR in an in vitro system, and find both aggregation and proteolytic processing of
the AR protein to occur in a polyglutamine repeat length-dependent manner. In addition, we
find the aberrant metabolism of expanded repeat AR to be coupled to cellular toxicity,
indicating a likely molecular basis for the toxic gain of AR function that produces neuronal …
expansion of a polyglutamine repeat within the androgen receptor (AR). We have studied
the mutant AR in an in vitro system, and find both aggregation and proteolytic processing of
the AR protein to occur in a polyglutamine repeat length-dependent manner. In addition, we
find the aberrant metabolism of expanded repeat AR to be coupled to cellular toxicity,
indicating a likely molecular basis for the toxic gain of AR function that produces neuronal …
Abstract
Spinal and bulbar muscular atrophy (SBMA) is a neurodegenerative disease caused by the expansion of a polyglutamine repeat within the androgen receptor (AR). We have studied the mutant AR in an in vitro system, and find both aggregation and proteolytic processing of the AR protein to occur in a polyglutamine repeat length-dependent manner. In addition, we find the aberrant metabolism of expanded repeat AR to be coupled to cellular toxicity, indicating a likely molecular basis for the toxic gain of AR function that produces neuronal degeneration in SBMA.
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