[PDF][PDF] Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer
T Takano, Y Ohe, H Sakamoto, K Tsuta… - J Clin …, 2005 - mhlw-grants.niph.go.jp
Purpose To evaluate epidermal growth factor receptor (EGFH) mutations and copy number
as predictors of clinical outcome in patients with non-small-cell lung cancer (NSCLC)
receiving gefitinib. Patients and Methods Sixty-six patients vvith NSCLC who experienced
relapse after surgery and received gefitinib were included. Direct sequencing of exons 18 to
24 of EGFF and exons 18 to 24 of EEBB2 was performed using DNA extracted from surgical
specimens. Pyrosequencing and quantitative real-time polymerase chain reaction were …
as predictors of clinical outcome in patients with non-small-cell lung cancer (NSCLC)
receiving gefitinib. Patients and Methods Sixty-six patients vvith NSCLC who experienced
relapse after surgery and received gefitinib were included. Direct sequencing of exons 18 to
24 of EGFF and exons 18 to 24 of EEBB2 was performed using DNA extracted from surgical
specimens. Pyrosequencing and quantitative real-time polymerase chain reaction were …